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5008/5008S Machine

• The 5008/5008S therapy system offers, for the first time, the dialysis therapy of choice Ä¢¹½´«Ã½“ ONLINE hemodiafiltration (HDF)^1-6ÌýÄ¢¹½´«Ã½“ with easy handling and thoughtful use of dialysis-relevant resources. It is a highly integrated system, built for sustainable dialysis Ä¢¹½´«Ã½“ today and in the future.
• ONLINE HDF Ä¢¹½´«Ã½“ a popular dialysis therapy choice^{1 -6}
• Monitoring of dialysis dose by OCM^® (online clearance monitoring and plasma sodium measurement)
• Single-needle method
• Long-term patient surveillance
• Well-designed user interface with large, clear touch-screen monitor
• Data management including device setting using a patient card (offline) and/or network integration (online)
• Online priming bolus and substitution reinfusion offering complete elimination of saline and irrigation bags
• Autoflow and Eco flow Ä¢¹½´«Ã½“ saving water, concentrates and energy
• Optional via the touch screen monitor are also available.
  These fully integrated options include:
  Blood pressure monitor (BPM)
  Blood temperature monitor (BTM)
  Blood volume monitor (BVM)
  Therapy Data Management System (TDMS)
  Ìý

References:
1. Locatelli F et al. J Am Soc Nephrol 2010:21:1798Ä¢¹½´«Ã½“807.
2. Carracedo J et al. J Am Soc Nephrol 2006;17:2315Ä¢¹½´«Ã½“21.
3. Gerdemann A et al. Nephrol Dial Tranplant 2002;17:1045Ä¢¹½´«Ã½“9.
4. Canaud B. Contrib Nephrol 2007;158:216Ä¢¹½´«Ã½“24.
5. Jirka T et al. Kidney Int 2006;70:1524Ä¢¹½´«Ã½“5.
6. Canaud B et al. Kidney Int 2006;69:2087Ä¢¹½´«Ã½“93

Biocompatible dialysers to meet the clinical needs of all patients

Dialysers

Fresenius Polysulfone^®Ìýbased dialysers combine high performance with excellent haemocompatibility and endotoxin retention.

FX-class of dialysers combine an innovative housing design with an advanced dialysis membrane Ä¢¹½´«Ã½“ known as Helixone^®. This membrane provides better performance, haemocompatibility and endotoxin retention capacity.

Manufacturing of the Helixone^® membrane involves a process known as Nano Controlled Spinning (NCS™) Technology, which allows the creation of a defined pore structure and distribution profile of the inner membrane layer according to the desired application.

Inline steam sterilisation -Ìý This complex procedure delivers dialysers and filters with an exceptionally high degree of purity characterised by:

Sterility and pyrogenicity

• Freedom from pore fillers
• Proven integrity of the membrane fibres
• Low rinsing volume 500 ml
  
  Dialysis fluid filters
  
  The quality and purity of the dialysis fluid are of major concern in renal replacement therapies, as large volumes of dialysis fluid come into contact with the patientÄ¢¹½´«Ã½™s bloodstream during each treatment. This is particularly the case with online haemodiafiltration (HDF), in which large fluid volumes are exchanged.
  
  Thus, the use of ultrapure dialysis fluid free from bacterial endotoxins and other microbial contamination is crucial in preventing undesirable acute reactions and influencing long-term patient outcomes. In addition, it has been shown to improve the control of anaemia, making it an important cornerstone of cardioprotective haemodialysis.¹
  
  The routine production of ultrapure dialysis fluid and substitution fluid (defined as endotoxins <0.03 IU/mL) relies on the implementation of ultrafilters Ä¢¹½´«Ã½“ such as the DIASAFE^®plus filter Ä¢¹½´«Ã½“ within the fluid pathway of the dialysis machine. DIASAFE^®plus filters are fitted as standard in the 5008/5008S therapy system and 4008S Next Generation to ensure a high degree of dialysis fluid purity.
  
  Plasma Filters
  
  PlasmaFlux PSu filters enable the elimination of a wide range of substances due to a sieving coefficient of 1 for molecules with a molecular weight of up to 2 million daltons. PlasmaFlux PSu filters contain the polysulfone-based Plasmasulfone^® membrane, which has been designed to minimise the activation of the patientÄ¢¹½´«Ã½™s immune system during bloodÄ¢¹½´«Ã½“­membrane interaction.
  
  Reference:
  1. Ledebo I. Hemodialysis International 2007;11:S12Ä¢¹½´«Ã½“S17.

Bloodlines and tubing systems

Ä¢¹½´«Ã½ bloodlines make a difference for both healthcare professionals and their patients by offering the following features:

• Compact and convenient components
• Medical grade raw materials fromÌýrenowned suppliers
• Certified quality systems for
• development and production
  
  Our bloodlines include:
  CAREsetÌý- The all-in-one 6008 cassette, its pre-connected bloodlines,
  compact design and lightweight material cover all treatment modalities and enables automatic connection to the integrated substitution unit on the 6008
  E-beamÌýsterilised bloodlines; a gentler process than the previously common gamma sterilisation and is also free of nuclear radiation (for use with the 5008/5008S therapy system and some on 4008S Next Generation)
  Ethylene oxideÌý(ETO) sterilised bloodlines. Special pre-conditioning and degassing process leads to minimised residual ETO content (for use with the 4008S Next Generation).

Disinfectants for haemodialysis

Ä¢¹½´«Ã½ formulates and manufactures Citrosterile® a disinfection, cleaning and descaling solution to help ensure the dialysis system is maintained.

Chemo-thermal disinfectants

• Use a combination of chemical and heat disinfection for haemodialysis machines with recirculation
• Odourless and biodegradable
• Must be used according to machine instructions at elevated temperatures only
• Removes Calcium, magnesium deposits and has active ingredients composed of natural substances