HighVolumeHDF® as easy as HD.
FX CorDiax
- Key features
- Technology
- Performance Data
- Studies
High selective permeability for middle molecules
The FX CorDiax is the most efficient dialyser within the FX class®. The core of the FX CorDiax is the Helixone®plus membrane, a targeted enhancement of the Helixone®Ա.
Refined membrane architecture
New production technology combined with INLINE steam sterilisation, allows for crucial enhancements of membrane porosity, reducing flow resistance and improving transport across the membrane.
Purity enhanced Ģý with steam
The benefits of INLINE steam sterilization | |
|---|---|
| No chemical residuals | No need for gamma sterilization Ģý high energy ionizing radiation can degrade and alter the material chemistry |
| Low rinsing volumes | Rinsing time and volume is substantially lower compared to gamma sterilized dialyzers |
| Less rinsing Ģý lower costs | Lower rinsing volumes mean reduced preparation costs |
INLINE steam sterilization process
Integrity test
Advances in fibre design allow for the better removal of uraemic toxins
- The fibre support region underneath the inner surface has been Ģýopened upĢý, optimising porosity and therefore also the convective filtration (ĢýflushingĢý) of larger uraemic toxins such as β2-DzDzܱ (≈ 11,800 Da) or myoglobin (≈ 17,000 Da)
- At the same time, the size of the pores of the inner surface area was not increased to avoid the flushing of albumin
Superior by design
| Optimised dialysate flow | The three-dimensional microwave structure of the fibres ensures uniform radial dialysate flow around each fibre within the bundle by preventing fluid channeling, therefore enhancing clearance values and improving the overall performance of the dialyser. |
| Better haemodynamics | The lateral blood-inlet port ensures more homogenous blood flow in the dialyser header, preventing stagnation zones. The design essentially minimises the risk of kinking, contributing to improved safety. |
| Enhanced convection | The more open structure of the Helixone®plus membrane support region serves to reduce diffusion resistance and increases convective filtration. This facilitates the clearance of a broad range of uraemic toxins, especially the middle molecules. |
| Kind to the environment | Advanced design goes beyond direct functionality; it also has to be easy on the environment. FX-class®dialysers weigh half as much as dialysers with polycarbonate housing, and at the same time, use ecologically friendly plastics. This means a lower carbon footprint as a result of fewer materials, less packaging, less fuel for transport and cleaner waste management. |
Key to optimal middle molecule removal
Solutes encounter resistance while traversing the membrane wall. Resistance to solute transport is affected in part by pore size at the inner surface and the porosity of the membrane wall. Furthermore, wall structure and thickness, inner fibre dimensions and three-dimensional microwave structure play important roles in transmembrane flux. The new membrane structure of Helixone®plusallows for the easy passage of middle molecules across the more porous support region of the membrane.
- The structure of the support region is crucial to overall performance
- Membrane porosity, together with the pore size, regulate the transport of middle molecules
Fibre design for HD
In an HD treatment, reducing the inner fibre diameter from 200 μm (F-series) to 185 μm (FX-class®) acts to increase internal filtration, thereby increasing the pressure gradient along the length of the fibre. This results in a greater pressure difference between the blood and dialysate compartments. Together with structural refinements to the support region of the fibres, this enables improvements in both diffusive and convective transport, which is of particular importance when performing High-Flux haemodialysis.
Benefit of reduced inner fiber diameter
Fiber pressure profile
Clearance versusthe inner diameter of fiber
FX CorDiax haemodiafilter
HighVolumeHDFtherapy requires specially designed filters. As a result, FX CorDiax haemodiafilters were developed for HighVolumeHDF
The benefit of enlarged fibre lumen in FX CorDiax haemodiafilters
Sieving coefficients of FX CorDiax High-Flux Dialysers and Haemodiafilters
| Sieving coefficients of FX CorDiax High-Flux Dialysers and Haemodiafilters | Molecular weight (Dalton) | |
|---|---|---|
| Albumin | 66,500 | < 0.001 |
| Myoglobin | 17,053 | 0.5 |
| β2-DzDzܱ | 11,731 | 0.9 |
| Inulin | 5,200 | 1 |
| Membrane material | Helixone®plus | |
| Sterilisation method | INLINE steam | |
| Housing material | Polypropylene | |
| Potting compound | Polyurethane | |
| Units per box | 24 |
FX CorDiax High-Flux Dialysers
| FX CorDiax High-Flux Dialysers | FXCorDiax40 | FXCorDiax50 | FXCorDiax60 | FXCorDiax80 | FXCorDiax100 | FXCorDiax120 | |
|---|---|---|---|---|---|---|---|
| Clearance (QB= 300 mL/min) | Molecular weight (Dalton) | ||||||
| Cytochrome c | 12,230 | 48 * | 76 | 96 | 111 | 125 | 136 |
| Inulin | 5,200 | 56 * | 88 | 116 | 127 | 144 | 149 |
| Vitamin B12 | 1,355 | 96 * | 144 | 175 | 190 | 207 | 213 |
| Phosphate | 132 | 142 * | 215 | 237 | 248 | 258 | 262 |
| Creatinine | 113 | 155 * | 229 | 252 | 261 | 272 | 274 |
| Urea | 60 | 175 * | 255 | 271 | 280 | 283 | 284 |
| Clearance (QB= 400 mL/min) | |||||||
| Cytochrome c | 12,230 | 100 | 117 | 133 | 145 | ||
| Inulin | 5,200 | 122 | 135 | 154 | 160 | ||
| Vitamin B12 | 1,355 | 191 | 209 | 229 | 237 | ||
| Phosphate | 132 | 270 | 285 | 299 | 305 | ||
| Creatinine | 113 | 290 | 303 | 321 | 325 | ||
| Urea | 60 | 319 | 336 | 341 | 343 | ||
| * Clearance (QB= 200 mL/min) | |||||||
| Ultrafiltration coeff. (mL/h x mmHg) | 21 | 33 | 47 | 64 | 74 | 87 | |
| In vitro performance: QD= 500mL/min, QF= 0mL/min, T = 37°C (ISO8637). Sieving coefficients: human plasma, QBmax, QF= 0.2 x QBmax (ISO8637). Ultrafiltration coefficients: human blood (Hct 32%, protein content 6%). | |||||||
| Effective surface (m2) | 0.6 | 1.0 | 1.4 | 1.8 | 2.2 | 2.5 | |
| K0A Urea | 547 | 886 | 1,164 | 1,429 | 1,545 | 1,584 | |
| Priming volume (mL) | 32 | 53 | 74 | 95 | 116 | 132 | |
| Article number | F00001588 | F00001589 | F00001590 | F00001591 | F00001592 | F00002384 | |
FX CorDiax Haemodiafilters
| FX CorDiax Haemodiafilters | FXCorDiax600 | FXCorDiax800 | FXCorDiax1000 | |
|---|---|---|---|---|
| Clearance (QB= 300 mL/min, QF= 75 mL/min) | Molecular weight (Dalton) | |||
| Cytochrome c | 12,230 | 131 | 141 | 151 |
| Inulin | 5,200 | 144 | 156 | 166 |
| Vitamin B12 | 1,355 | 204 | 217 | 225 |
| Phosphate | 132 | 257 | 267 | 271 |
| Creatinine | 113 | 271 | 277 | 280 |
| Urea | 60 | 285 | 291 | 292 |
| Clearance (QB= 400 mL/min, QF= 100 mL/min) | ||||
| Cytochrome c | 12,230 | 149 | 160 | 172 |
| Inulin | 5,200 | 166 | 178 | 190 |
| Vitamin B12 | 1,355 | 235 | 251 | 262 |
| Phosphate | 132 | 307 | 321 | 328 |
| Creatinine | 113 | 327 | 339 | 343 |
| Urea | 60 | 354 | 365 | 367 |
| Ultrafiltration coeff. (mL/h x mmHg) | ||||
| In vitro performance: QD= 500 mL/min, T = 37°C (ISO8637). Sieving coefficients: human plasma, QBmax, QF= 0.2 x QBmax (ISO8637). Ultrafiltration coefficients: human blood (Hct 32%, protein content 6%). | ||||
| Effective surface (m2) | 1.6 | 2.0 | 2.3 | |
| K0A Urea | 1,148 | 1,365 | 1,421 | |
| Priming volume (mL) | 95 | 115 | 136 | |
| Article number | F00001593 | F00001594 | F00001595 | |
FX CorDiax has a high middle molecule removal capacity
Maduellet al.determined the removal capacity of FX CorDiax 60 compared to FX 60 in HDF postdilution treatments. Significantly higher removal rates were observed with FX CorDiax for:
- Urea (60 Da)
- β2-DzDzܱ (11.8 kDa)
- Myoglobin (17.2 kDa)
- Prolactin (22.9 kDa)
- α1-microglobulin (33 kDa)
The authors concluded that ĢýĢý treating patients with online hemodiafiltration and FX CorDiax 60 instead of FX 60 dialysers results in significantly increased reduction ratios of middle sized molecules without clinically relevant changes in albumin loss.Ģý
Comparison of albumin loss in a post-dilution HDF treatment
(QB = 350 mL/min, QD = 800 mL/min, QS = 80 mL/min)4
| Albumin loss (g/four hours) | |
|---|---|
| FX CorDiax 100 | 1.74 ± 1.01 |
| FX 100 | 2.10 ± 1.00 |
| Polyflux®21 OH | 1.31 ± 0.12 |
The phosphate clearance of FX CorDiax dialysers
Comparison of aqueous in-vitro clearances of phosphate (QB = 300 ml/min, QD = 500 ml/min). Investigations carried out by EXcorLab GmbH, an accredited calibration and testing laboratory.
If you would like to order this product via the NHS Supply Chain Catalogue, please visit the following link:
Additional information relating to multiBic or Calrecia can be found in the critical care section of ourproduct information page.
Adverse Events Reporting
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellowcard in the Google Play or Apple App Store. Adverse events should also be reported to Ģý on 01623 445215 or VigilanceUK@freseniusmedicalcare.com
UK-All-000020. Date of Preparation: June 2026.
Related content
1Dellanna F. et al., (1996); Nephrology Dialysis Transplantation 11 (Suppl 2): 83-86.
2Vega Vega O. et.al.; ERA-EDTA Congress 2012, Poster 457ĢýFP.
3Maduell et. al.; ERA-EDTA Congress 2013, May 20, Poster Number MP 390.
4Bock A. et al., Journal of the American Society of Nephrology (2013); 24: SA-PO404.